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apalutamide will minimize the extent or impact of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with prescription drugs that are CYP2C19 substrates may lead to decreased exposure to those medications.Ahead of use, instruct specific administe